Courses of Instruction

The terms indicated are expected but are not guaranteed. For the courses offered during any given term, consult the Schedule of Classes.

Biochemistry and Molecular Biology (BIOC)

401ab Medical Biochemistry (5, 3) Introduction to biochemistry emphasizing human and medical aspects, including the specific biochemistry of various human organ systems. Discussion groups in fall semester.

490x Directed Research (4) Designed to give undergraduate students a research opportunity with selected Biochemistry Department faculty. Students will work out details of the research with individual faculty members. Not available for credit to Biological Sciences majors. Prerequisite: BIOC 441 or BISC 216L.

501 Recent Advances in Biochemistry (2-4, max 16, Fa) Lectures on areas of intermediary metabolism and the chemistry of natural products. Prerequisite: BISC 435, CHEM 430ab.

502 Biochemistry Seminar (1, max 12, FaSp) Formal presentations and discussion by students of material from research literature.

503 Chemical Reaction Mechanisms in Biochemistry (4, 2 years, Fa) Mechanisms of reactions of interest in biochemistry from the standpoint of modern organic chemistry; hydrolytic and other reactions in aqueous systems and enzymatic reactions. Prerequisite: BISC 435, CHEM 430ab. (Fife)

504 Molecular Biology of Cancer (4) (Enroll in INTD 504)

505 Cofactor Catalyzed Reactions (2, 2 years, Fa) The mechanism of action of coenzymes such as pyridoxal, thiamin, NAD, tetrahydrofolic acid, etc.; their effects on enzymatic reactions, and the chemistry of related nonenzymatic reactions. Prerequisite: general biochemistry. (Fife)

506 Enzyme Kinetics and Mechanisms (2, 2 years, Sp) Theory and application of kinetic methods to the investigation of the mechanism of enzyme action. Prerequisite: general biochemistry. (Danenberg, Fife)

520 Membranes: Structures and Functions (2, 2 years, Sp) Current concepts of membranes; associated reactions; oxidative phosphorylation; transport of sugars, ions, amino acids, and conformational change. Prerequisite: general biochemistry. (Kalra, Levy)

530 Biochemistry of Anti-Cancer Agents (2, 2 years, FaSp) Biochemical effects of antimetabolites, alkylating agents, vinca alkaloids, and other drugs on cancer cells. Detailed mechanisms of cytotoxicity and the emergence of drug resistance. Prerequisite: organic chemistry. (Danenberg, Moran)

531 Cell Biology (4) (Enroll in INTD 531)

536 Biochemistry of Cell-Cell Recognition (2, Irregular) Cell surface-related biochemical events during developmental stages; cell-cell communication through certain receptors; liposomes as models for cellular interactions. Prerequisite: one year general biochemistry. (Tokes)

542 Cellular and Molecular Basis of Animal Development (4, Fa) Processes of cell type specification, determination, and morphogenesis in metazoans from vertebrates to insects. Genetic, paragenetic and molecular biological approaches to developmental processes. Prerequisite: INTD 571.

549 Protein Chemistry and Structure (3, 2 years, Sp) Chemistry of peptides and proteins; physical and chemical methods applied to isolation and study of protein structure; proteinase action; protein modeling, molecular and secondary structure prediction. Prerequisite: general biochemistry.

551 Procaryotic Molecular Genetics (4, Fa) (Enroll in MICB 551)

555 Biochemical and Molecular Bases of Disease (4) (Enroll in INTD 555)

561 Molecular Genetics (4, Sp) (Enroll in INTD 561)

562 Systems and Integrative Physiology (4, Sp) (Enroll in PHBI 562)

571 Biochemistry (4, Fa) (Enroll in INTD 571)

590 Directed Research (1-10, FaSpSm) Research leading to the master's degree. Maximum units which may be applied to the degree to be determined by the department. Graded CR/NC.

594abz Master's Thesis (2-2-0, FaSpSm) Credit on acceptance of thesis. Graded IP/CR/NC.

599 Special Topics (2-4, max 8)

601 Molecular Biology of Gene Regulation (2, max 8, FaSp) Current techniques and systems in molecular biology from an interdisciplinary perspective: microbiological, biochemical, and pharmaceutical.

602 Current Topics in Human Molecular Genetics (2) Current research in human genetics, including positional cloning of genes, mutational analysis of disease genes, construction and characterization of animal models, and gene therapy. Prerequisite: BIOC 551 and BIOC 561. (Reichardt, Anderson, Cortopassi)

790 Research (1-12, FaSpSm) Research leading to the doctorate. Maximum units which may be applied to the degree to be determined by the department. Graded CR/NC.

794abcdz Doctoral Dissertation (2-2-2-2-0, FaSpSm) Credit on acceptance of dissertation. Graded IP/CR/NC.

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